The report is devoted to the study of stress concentration in orthotropic plates with holes. The analytical method and the finite element method are used. The finite element method is used to analyze the effect of the parameter of the ratio of the hole radius to the characteristic dimensions of the plate on the stress distribution. Quantitative patterns of changes in the stress concentration factor depending on the degree of orthotropy of the material and the geometric parameters of the structure have been established. The results obtained make it possible to predict the stress-strain state of plates with holes made of orthotropic materials in engineering calculations.